Chicago Cancer Center, Robert H. Lurie Comprehensive Cancer Center, Northwestern

The Basic Sciences Research Division of Robert H. Lurie Comprehensive Cancer Center of Northwestern University includes faculty who investigate all aspects of cell function from misappropriated extracellular matrix to nuclear transcription factors, from biomaterials to cutting edge imaging techniques, and from prognostics, diagnostics, to therapeutics. This Division is led by Tom O'Halloran. If you would like more information on the Basic Sciences Research Division, call the Basic Research Initiatives Office at 847-467-2587.

Research Programs and Themes

Members

Viral Oncogenesis

	Mechanisms of Viral Oncogenesis
	Viral Replication Strategies
	Host Pathogenesis and Immune Modulation
	Therapeutic Intervention and Animal Models of Viral Infection and Oncogenesis

Members

Tumor Invasion, Metastasis and Angiogenesis (TIMA)

	Cell-Cell and Cell-Matrix Interaction, Adhesion Receptor Signaling
	Matrix Structure, Assembly, and Remodeling
	Mechanisms and Regulation of Motility
	Vascular Biology

Members

Hormone Action and Signal Transduction in Cancer

	Mechanisms of Ligand-Receptor Interaction in Normal and Tumor Cells
	Signal Transduction Pathways in Normal and Neoplastic Cells
	Cellular Responses to Tumor-Derived Hormones and Growth Factors
	Impact of Anticancer Therapeutic and Chemopreventive Agents on Signal Transduction Pathways: Translational component of the HAST program

Members

Cancer Genes and Molecular Targeting

	Mechanisms and Pathways Controlling Cell Growth, Differentiation and Oncogenesis
	Development novel diagnostic agents and techniques that facilitate early detection of cancer
	Discovery of New Classes of Therapeutic Agents

Members

Cancer Cell Biology

	Post-transcriptional regulation
	Subcellular localization of proteins and DNA
	Control of Cell Fate Determination
	Cancer animal model and therapeutics