Mechanisms and Regulation of Motility

Research Team:  Chenn, Chew, Gelfand, Goldman, Jones, LaBonne, Rice, Stack

Migration is an essential component of normal developmental processes; however acquisition of a motile phenotype is a key requirement for both hematogenous and intraperitoneal metastasis as well as for tumor neovascularization. This group is comprised of researchers who study the fundamental process of cell movement; the biological, biochemical and biophysical structures that contribute to a motile phenotype; and regulation of cellular migration. Research is focused on analysis of molecular motor structure and function and cytoskeletal assembly (Gelfand, Goldman, Rice). Additional investigators utilize a variety of approaches employing model organisms, metastatic tumor cells, and tumor cell-endothelial cell interactions to elucidate the cellular signaling pathways that contribute to acquisition of invasiveness (Chenn, Chew, Jones, LaBonne, Stack).

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