Cancer animal model and therapeutics

Research Team:  Eklund, Kessler, Kiyokawa, Licht, Rao, Reddy, Roy, Wali

Rodent models of cancer (Eklund, Kessler, Kiyokawa, Licht, Rao, Reddy, Roy, Wali)
Animal models have been essential for cancer research. In particular, genetically engineered mouse models, such as knockout, knockin, and transgenic mice, continue to be powerful tools to dissect complex pathways involved in cancer development and progression. A number of Cancer Cell Biology members utilize mouse and rat models for their research. For example, Eklund studies phenotypes of HOXA10- and ICSBP-knockout mice, which provide critical insights into leukemia development. Kiyokawa has developed and characterized several knockout mouse models with mutations in CDK-regulatory pathways, including Cdk4- and Cdc25A-knockout mice, which are resistant to carcinogenesis. Licht generated Sprouty knockout mice and showed that this protein critical for WT1 signaling. Reddy has developed and studied several mouse models to study the peroxisome proliferators activated receptors (PPAR)-mediated signaling and liver carcinogenesis. Roy and Wali are experts in the chemoprevention area using rat colon cancer models. Their study using light scattering spectroscopy represents translational studies that take full advantage of novel technology and cancer animal models.

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