Mechanisms and Pathways Controlling Cell Growth, Differentiation and Oncogenesis

Research Team:  Anderson, Chisholm, Huang, Mondragon, O'Halloran, Ouchi, Pasche, Radhakrishnan, Rosenzweig, Widom, Yeldani

Members of the Cancer Genes and Molecular Targeting Program are investigating the key genetic, biochemical and structural characteristics of factors associated with cellular transformation. These molecules include oncogenes, tumor suppressor genes and regulatory enzymes involved in cell growth and differentiation. The aberrant expression of these genes is a hallmark of cancer. Members of the Program are studying the structure and functional characteristics of DNA and RNA, including defining essential components involved in transcriptional regulation (Anderson, Mondragon, Radahakrishnan, Widom); evaluating important signaling molecules and enzymes that produce them (Pasche, Ouchi, O'Halloran, Rosenzweig); and identifying genetic alterations associated with cancer (Huang, Kaul, Ouchi, Pasche,). Further understanding of these concepts will serve as a springboard for new diagnostic tools as well as strategies for the development of new therapeutic agents.

Previous Page